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These activated T cells release proinflammatory cytokines (eg, tumor necrosis factor alpha), which trigger a robust immune response that leads to inflammation, tissue injury, and necrosis across multiple organ systems, including the skin, liver, kidneys, lungs, and heart
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In the presented case, the onset of rash less than 2 weeks following sorafenib initiation and absence of eosinophilia, lymphadenopathy, or multi-organ involvement ultimately favored the diagnosis of sorafenib toxicity.The overall incidence of rash and/or desquamation in sorafenib toxicity is estimated to be 35.4%
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