As the game continues your Leader effect is bound to activate, so there's no need to excessively reduce your own Life with the effect of "OP03-110 Charlotte Smoothie." Save it for the end of the game, when you want to pile it on to finish the opponent
A really funny combo would be Intruder Alarm plus Torpor Orb, which keeps creatures tapped down
Molt Tender doubles as a way to Mill yourself to further maximize Icetill Explorer
[D][C] Smog Burst: 20+ damage
Cards like The Queen, Commanding Presence and Gaston, Intellectual Powerhouse are about as tricky as things get, but they simply do what they say on the card and get players used to the powerful (at least in my eyes) shift mechanic, which is a cost reduction method
Crystal Edge A good number of Pokmon- EX have attacks that hit for 150 damage