There is an occasional exception to that as a few of the APs remaining from very early editions were signed with a silver pen
One of the most powerful ways to use Myriad is in a way where you can avoid the tokens you create disappearing at the end of the turn
I think Guiltfeeder usually kills quickly, as does Her Highness Phage the Untouchable

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We don't yet know if the cards will use the old template and wording, or the the more modern ones
Sure, the original Viscera Seer cards still carry significant value and are extremely rare (only 100 made)